Tuesday, April 30, 2013
Stil waiting..:(
They still haven't received it, it's been 15 days since they went off with USPS... now I'm really worried :((((
Monday, April 29, 2013
Worries worries worries
My records haven't reached the hospital in Denmark...em... FedEx charges nearly $210 so I chose USPS...I might regret being cheap on this very soon:(
Give me a reason to have confidence in you, USPS!!
Give me a reason to have confidence in you, USPS!!
Wednesday, April 24, 2013
Endometrial injury to overcome recurrent embryo implantation failure
Interesting article-------->
Mechanical endometrial injury (biopsy/scratch or hysteroscopy) in the cycle preceding ovarian stimulation for IVF has been proposed to improve implantation in women with unexplained recurrent implantation failure (RIF). This is a systematic review and meta-analysis of studies comparing the efficacy of endometrial injury versus no intervention in women with RIF undergoing IVF. All controlled studies of endometrial biopsy/scratch or hysteroscopy performed in the cycle preceding ovarian stimulation were included and the primary outcome measure was clinical pregnancy rate. Pooling of seven controlled studies (four randomized and three non-randomized), with 2062 participants, showed that local endometrial injury induced in the cycle preceding ovarian stimulation is 70% more likely to result in a clinical pregnancy as opposed to no intervention. There was no statistically significant heterogeneity in the methods used, clinical pregnancy rates being twice as high with biopsy/scratch (RR 2.32, 95% CI 1.72–3.13) as opposed to hysteroscopy (RR 1.51, 95% CI 1.30–1.75). The evidence is strongly in favour of inducing local endometrial injury in the preceding cycle of ovarian stimulation to improve pregnancy outcomes in women with unexplained RIF. However, large randomized studies are required before iatrogenic induction of local endometrial injury can be warranted in routine clinical practice.
Some women undergoing IVF treatment fail to conceive despite several attempts with good-quality embryos and no identifiable reason. We call this ‘recurrent implantation failure’ (RIF) where the embryo fails to embed or implant within the lining of the womb. Studies have shown that inducing injury to the lining of the womb in the cycle before starting ovarian stimulation for IVF can help improve the chances of achieving pregnancy. Injury can be induced by either scratching the lining of the womb using a biopsy tube or by telescopic investigation of the womb using a camera. We performed a collective review of the available good-quality studies that used the above two methods in the cycle prior to starting ovarian stimulation for IVF. We pooled results from seven studies, which included 2062 women with RIF and assessed the difference in clinical pregnancy rates for those undergoing injury to the womb lining compared with no injury prior to IVF. The results suggest that inducing injury is 70% more likely to result in a clinical pregnancy as opposed to no treatment. Furthermore, scratching of the lining was 2-times more likely to result in a clinical pregnancy compared with telescopic evaluation of the lining of the womb. This study suggests that in women with RIF, inducing local injury to the womb lining in the cycle prior to starting ovarian stimulation for IVF can improve pregnancy outcomes. However, large studies are required before this can be warranted in routine clinical practice.
Mechanical endometrial injury (biopsy/scratch or hysteroscopy) in the cycle preceding ovarian stimulation for IVF has been proposed to improve implantation in women with unexplained recurrent implantation failure (RIF). This is a systematic review and meta-analysis of studies comparing the efficacy of endometrial injury versus no intervention in women with RIF undergoing IVF. All controlled studies of endometrial biopsy/scratch or hysteroscopy performed in the cycle preceding ovarian stimulation were included and the primary outcome measure was clinical pregnancy rate. Pooling of seven controlled studies (four randomized and three non-randomized), with 2062 participants, showed that local endometrial injury induced in the cycle preceding ovarian stimulation is 70% more likely to result in a clinical pregnancy as opposed to no intervention. There was no statistically significant heterogeneity in the methods used, clinical pregnancy rates being twice as high with biopsy/scratch (RR 2.32, 95% CI 1.72–3.13) as opposed to hysteroscopy (RR 1.51, 95% CI 1.30–1.75). The evidence is strongly in favour of inducing local endometrial injury in the preceding cycle of ovarian stimulation to improve pregnancy outcomes in women with unexplained RIF. However, large randomized studies are required before iatrogenic induction of local endometrial injury can be warranted in routine clinical practice.
Some women undergoing IVF treatment fail to conceive despite several attempts with good-quality embryos and no identifiable reason. We call this ‘recurrent implantation failure’ (RIF) where the embryo fails to embed or implant within the lining of the womb. Studies have shown that inducing injury to the lining of the womb in the cycle before starting ovarian stimulation for IVF can help improve the chances of achieving pregnancy. Injury can be induced by either scratching the lining of the womb using a biopsy tube or by telescopic investigation of the womb using a camera. We performed a collective review of the available good-quality studies that used the above two methods in the cycle prior to starting ovarian stimulation for IVF. We pooled results from seven studies, which included 2062 women with RIF and assessed the difference in clinical pregnancy rates for those undergoing injury to the womb lining compared with no injury prior to IVF. The results suggest that inducing injury is 70% more likely to result in a clinical pregnancy as opposed to no treatment. Furthermore, scratching of the lining was 2-times more likely to result in a clinical pregnancy compared with telescopic evaluation of the lining of the womb. This study suggests that in women with RIF, inducing local injury to the womb lining in the cycle prior to starting ovarian stimulation for IVF can improve pregnancy outcomes. However, large studies are required before this can be warranted in routine clinical practice.
Sunday, April 21, 2013
Update, crazy week
Boston and Bostonians, you are strong and you will heal with strength and love coming from all over the world.
Following the colposcopy & biopsy from the "abnormal PAP", it turned out to be benign, thankfully. I had a make up FSH done because the lab had somehow lost my blood and no one realized until I asked. FSH – 7.8 Estradiol – 28.5 DHEA level has increased from18-29 and my AMH is 1.6, which seems better than the 1.28 from 3 years ago, even though I know it fluctuates, it still makes me feel better...small victories??
Our crazy move has almost finished, all big things have been moved except some small pieces. OYYYYE.
Following the colposcopy & biopsy from the "abnormal PAP", it turned out to be benign, thankfully. I had a make up FSH done because the lab had somehow lost my blood and no one realized until I asked. FSH – 7.8 Estradiol – 28.5 DHEA level has increased from18-29 and my AMH is 1.6, which seems better than the 1.28 from 3 years ago, even though I know it fluctuates, it still makes me feel better...small victories??
Our crazy move has almost finished, all big things have been moved except some small pieces. OYYYYE.
Monday, April 15, 2013
3 days late for period
I've read that DHEA can delay period, and it's happening! I've had cramps for 3 days but nothing came so far!
Sunday, April 14, 2013
OFF WITH THE RECORDS
Finally put together my records and will be sending them off to Denmark tomorrow. I'm excited and anxious--would this be the game changer? Would DHEA be my ultimate savior? Would.....?
There are SO many questions that can't be answered by anyone by time, and I'm so afraid of more disappointment...yet we are still doing everything we can so we can have an opportunity to try....to try!! :(
There are SO many questions that can't be answered by anyone by time, and I'm so afraid of more disappointment...yet we are still doing everything we can so we can have an opportunity to try....to try!! :(
Friday, April 12, 2013
DHEA and its side-effects
Pretty good pictorial depiction of me on DHEA----
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